Resveratrol supplementation and dosage (David Sinclair’s personal experience)

– [Dr. Sinclair]: Resveratrol’s probably not
going to hurt me and it may very well help my cardiovascular system. – [Dr. Patrick]: It seems to be really important
for a cardiovascular system, like… And I’m just kind of, do you know why, why
is it…? – [Dr. Sinclair]: We have a number of ideas. And resveratrol is a dirty molecule, so there’s
not just one way it works. Sirtuins definitely are involved. We now have a mouse that’s mutant for the
resveratrol activation of SIRT1, so we now see that some aspects, like endurance, of
resveratrol seem to be through SIRT1. So one of the effects is through SIRT1’s anti-inflammatory
actions in the lining of the blood vessels, the endothelial cells. – [Dr. Patrick]: Oh. Okay. – [Dr. Sinclair]: Yeah. That seems to be important. And there’s other aspects also in DNA repair
as well. infiltration of macrophages in there seems
to be dampened. And we also looked at oxidative stress in
those arteries of those mice treated and it was way down in the resveratrol mice. – [Dr. Patrick]: Yeah. With the rhesus monkeys, with the, you know,
basically like, you know, completely reversing that 40% aortic stiffness, that’s like pretty,
it’s a pretty dramatic effect. So I was… – [Dr. Sinclair]: It is. And so, yeah, I think resveratrol, it’s… People are, you know, “Oh, is it true, is
it not?” “60 Minutes” did a story and then there was
an argument about how it was working. And so people are confused about the molecule,
and I still stand by it because the results, like you say, in animals. And there are clinical studies now that are
really positive in humans. Not all of them, sometimes it has no effect. There was one study where it interfered with
endurance exercise. Don’t understand that. – [Dr. Patrick]: Metformin was kind of shown
to do something similar where it prevented mitochondrial adaptations in [crosstalk 00:47:47]
but who knows? – [Dr. Sinclair]: I mean, maybe… Rhonda, what’s maybe happening is that if
you’re dampening free radicals too much, you’re actually losing that benefit. – [Dr. Patrick]: Hormetic effect. – [Dr. Sinclair]: Exactly. The mitohormesis. But I haven’t seen any downside. You know, I’m a N-of-one, as you would say,
in a clinical trial. I’ve had my heart checked out with a 3D movie
MRI. My heart looks like it’s 20, it’s got no sign
of aging. So, it doesn’t seem to be doing myself and
my dad any harm. So… – [Dr. Patrick]: How long have you been taking
it? – [Dr. Sinclair]: Oh, geez. Since 2003. – [Dr. Patrick]: Wow. And you take about a gram [inaudible 00:48:22]
or so a day. Yeah.